132303-29-8Relevant articles and documents
The use of (S)-(-)-1-(1-naphthyl)ethylamine as a resolving agent for α- methoxy fatty acids
Carballeira, Nestor M.,Colon, Roberto
, p. 3785 - 3790 (1999)
A general method was developed for the diastereoselective resolution of α-methoxy fatty acids utilizing (S)-(-)-1-(1-naphthyl)ethylamine as resolving agent. The diastereomeric amides can be easily separated by silica gel column chromatography and/or capillary gas chromatography, thus allowing for a preparative and analytical method for determining the enantiomeric purity of naturally occurring and/or synthetic α-methoxy fatty acids. The first synthesis of the naturally occurring (R)-2-methoxyhexadecanoic acid was also accomplished in four steps starting from commercially available (±)-2- hydroxyhexadecanoic acid.
