132465-10-2 Usage
Description
2-(1-THIENYL)ETHYL-3,4-DIHYDROXYBENZYLIDENE-CYANOACETATE, also known as 2-TEDC, is an organic compound with the chemical formula C16H13NO3S. It is a reagent used in the synthesis of various compounds, particularly caffeic acid derivatives, which have demonstrated significant biological activities.
Uses
Used in Pharmaceutical Industry:
2-TEDC is used as a reagent for the preparation of caffeic acid derivatives, which possess potent inhibitory activities on 12-lipoxygenase. This enzyme plays a crucial role in various inflammatory processes, making caffeic acid derivatives potential candidates for the development of anti-inflammatory drugs.
Used in Research and Development:
In the field of research and development, 2-TEDC serves as a valuable starting material for the synthesis of novel compounds with potential applications in various therapeutic areas. Its unique chemical structure allows for the exploration of new chemical entities that may exhibit improved pharmacological properties compared to existing drugs.
Used in Chemical Synthesis:
2-TEDC is also utilized in chemical synthesis processes, where it can be employed to create a wide range of compounds with diverse applications. Its versatility as a reagent makes it a valuable tool for chemists working on the development of new molecules for various industries, including pharmaceuticals, agrochemicals, and materials science.
Biological Activity
Potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC 50 values are 0.09, 0.013 and 0.5 μ M respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 132465-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,6 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 132465-10:
(8*1)+(7*3)+(6*2)+(5*4)+(4*6)+(3*5)+(2*1)+(1*0)=102
102 % 10 = 2
So 132465-10-2 is a valid CAS Registry Number.
132465-10-2Relevant articles and documents
Stereochemistry of Knoevenagel condensation products from cyanoacetates and aromatic aldehydes
Cho,Iwashita,Hamaguchi,Oyama
, p. 3341 - 3342 (2007/10/02)
The C-13 long-range selective proton decoupling method and X-ray crystallographic analysis were employed to determine the stereochemistry of the caffeic acid derivatives, extremely potent 12-lipoxygenase inhibitors, synthesized from cyanoacetates and arom
DERIVATIVE OF CAFFEIC ACID AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
, (2008/06/13)
Novel derivatives of caffeic acid of the general formula (I): wherein X is hydrogen atom or hydroxy; R 1 is hydrogen atom, a straight or branched alkyl or alkenyl having 1 to 20 carbon atoms or a group of the formula wherein n is an integer of 1 to 10; Z
