132470-83-8

Basic information

• Product Name: 4-Trifluoromethyl-pyridine-2-carbaldehyde
• Synonyms: 4-Trifluoromethyl-pyridine-2-carbaldehyde;4-(TrifluoroMethyl)picolinaldehyde;4-(Trifluoromethyl)pyridine-2-carboxaldehyde;4-(trifluoromethyl)-2-Pyridinecarboxaldehyde
• CAS NO: 132470-83-8
• Molecular Formula: C₇H₄F₃NO
• Molecular Weight: 175.11
• Mol File: 132470-83-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 194.351 °C at 760 mmHg
• Flash Point: 71.341 °C
• Appearance: /
• Density: 1.37 g/cm³
• Refractive Index: 1.476
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.54±0.10(Predicted)
• CAS DataBase Reference: 4-Trifluoromethyl-pyridine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Trifluoromethyl-pyridine-2-carbaldehyde(132470-83-8)
• EPA Substance Registry System: 4-Trifluoromethyl-pyridine-2-carbaldehyde(132470-83-8)

Safety Data

• Hazardous Substances Data: 132470-83-8(Hazardous Substances Data)

Usage

General Description

4-Trifluoromethyl-pyridine-2-carbaldehyde is a chemical compound containing a trifluoromethyl group, a pyridine ring, and an aldehyde functional group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 4-Trifluoromethyl-pyridine-2-carbaldehyde is known for its strong odor and is classified as a hazardous substance. It is important to handle and store 4-Trifluoromethyl-pyridine-2-carbaldehyde with caution to avoid potential health hazards. This chemical is commonly used in the field of medicinal and organic chemistry for the development of new drugs and materials due to its unique structural properties.

InChI:InChI=1/C7H4F3NO/c8-7(9,10)5-1-2-11-6(3-5)4-12/h1-4H

Upstream product

• 1401100-81-9 4-(trifluoromethyl)-2-vinylpyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 175205-81-9 2-bromo-4-(trifluoromethyl)pyridine 
• 588702-62-9 4-(trifluoromethyl)-2-pyridinecarboxylic acid 
• 131747-39-2 [4-(trifluoromethyl)pyridin-2-yl]methyl acetate 
• 131748-17-9 4-Trifluoromethyl-2-picoline-N-oxide 
• 81565-18-6 2-chloro-4-trifluoromethyl pyridine 
• 131747-46-1 (4-trifluoromethyl-pyridin-2-yl)-methanol 

Downstream Products

• 131747-46-1 (4-trifluoromethyl-pyridin-2-yl)-methanol 
• 215867-87-1 2-(chloromethyl)-4-(trifluoromethyl)pyridine 
• 108337-81-1 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 

Relevant articles and documents

ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

BTK INHIBITORS

The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.