132475-60-6

Basic information

• Product Name: 2-BROMO-N-HYDROXY-BENZAMIDINE
• Synonyms: 2-BROMO-N-HYDROXY-BENZAMIDINE;2-BROMO-N-HYDROXYBENZIMIDAMIDE;Benzenecarboximidamide,2-bromo-N-hydroxy-
• CAS NO: 132475-60-6
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• Mol File: 132475-60-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 367.2 °C at 760 mmHg
• Flash Point: 175.9 °C
• Appearance: /
• Density: 1.68 g/cm³
• CAS DataBase Reference: 2-BROMO-N-HYDROXY-BENZAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N-HYDROXY-BENZAMIDINE(132475-60-6)
• EPA Substance Registry System: 2-BROMO-N-HYDROXY-BENZAMIDINE(132475-60-6)

Safety Data

• Hazardous Substances Data: 132475-60-6(Hazardous Substances Data)

Usage

General Description

2-BROMO-N-HYDROXY-BENZAMIDINE is a chemical compound that is a derivative of benzamidine. It is a white to off-white solid that is used as an inhibitor in biological research, particularly in the study of proteases and enzymes. 2-BROMO-N-HYDROXY-BENZAMIDINE is known for its ability to selectively inhibit specific enzymes, making it a valuable tool in the study of various biochemical processes. Its structure and properties make it a useful reagent in the development of new drugs and in the investigation of disease pathways. The chemical is also used in the synthesis of pharmaceuticals and has potential applications in the treatment of various medical conditions.

Upstream product

• 34158-72-0 2-bromobenzaldehyde oxime 
• 6630-33-7 ortho-bromobenzaldehyde 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 1430424-10-4 C₂₁H₁₉BrClN₃O₂ 
• 343269-59-0 N-(2-bromophenyl)cyanamide 
• 132293-60-8 SbCl₅N(OH)C(NH₂)C₆H₄Br 
• 90224-62-7 3-(2-bromo-phenyl)-5-chloromethyl-[1,2,4]oxadiazole 
• 110722-39-9 {3-[3-(2-Bromo-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid ethyl ester 
• 110703-55-4 {3-[3-(2-Bromo-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 

Relevant articles and documents

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.

TiO2-Nanoparticles Catalyzed Synthesis of New Trifluoromethyl-4,5-dihydro-1,2,4-oxadiazoles and Trifluoromethyl-1,2,4-oxadiazoles

Synthesis of a new series of trifluoromethyl-4,5-dihydro-1,2,4-oxadiazoles and trifluoromethyl-1,2,4-oxadiazoles have been described by utilizing the reactions between amidoximes and trifluoroacetimidoyl chlorides. Trifluoromethyl-4,5-dihydro-1,2,4-oxadia