132553-87-8

Basic information

• Product Name: (R)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol
• CAS NO: 132553-87-8
• Molecular Weight: 295.425
• Mol File: 132553-87-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol(132553-87-8)
• EPA Substance Registry System: (R)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol(132553-87-8)

Safety Data

• Hazardous Substances Data: 132553-87-8(Hazardous Substances Data)

Upstream product

• 133906-84-0 Acetic acid (R)-(1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 
• 133844-27-6 Acetic acid (1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 
• 107703-78-6 glemanserin 
• 38081-60-6 phenyl-piperidin-4-yl-methanol 
• 103-63-9 1-phenyl-2-bromoethane 
• 4455-09-8 2-phenylethyl tosylate 

Downstream Products

• 133844-27-6 Acetic acid (1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 
• 132553-88-9 (S)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol 
• 133906-84-0 Acetic acid (R)-(1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 

Relevant articles and documents

An efficient synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione. Synthesis of isoguvacine and MDL-11,939

An efficient route towards the synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione using various N-alkyl-α-sulfonylacetamides and two α,β-unsaturated esters as starting materials is described. Isoguvacine and MDL-11,939 with have potential biological activities were synthesized via this strategy.

ENZYMATIC RESOLUTION OF AN ARYLPIPERIDINE DERIVATIVE UTILIZING LIPASE CATALYZED HYDROLYSIS

Enantiospecific hydrolysis of the acetate 1 was carried out on a multigram scale utilizing a lipase from Aspergillus niger.Both stereoisomers R-(+) and S-(-) were obtained with high enantiomeric purity (>97 percent ee).