132567-84-1Relevant articles and documents
Fluorene Complexes of Group 9 Metals: Fluorene Effect and Application for Reductive Amination
Kharitonov, Vladimir B.,Podyacheva, Evgeniya,Nelyubina, Yulia V.,Muratov, Dmitry V.,Peregudov, Alexander S.,Denisov, Gleb,Chusov, Denis,Loginov, Dmitry A.
, p. 3151 - 3158 (2019)
The η6-fluorene cyclopentadienyl complexes [(η5-C5R5)M(η6-fluorene)](SbF6)2 (1: M = Co, R = Me; 2a: M = Rh, R = H; 2b: M = Ir, R = H) were synthesized by the iodide abstraction f
Phosphine ligands in the ruthenium-catalyzed reductive amination without an external hydrogen source
Makarova, Maria,Afanasyev, Oleg I.,Kliuev, Fedor,Nelyubina, Yulia V.,Godovikova, Maria,Chusov, Denis
, (2021/04/15)
A systematic study of the phosphine additives influence on the activity of a ruthenium catalyst in reductive amination without an external hydrogen source was carried out. [CymeneRuCl2]2 was used as a reference catalyst, and a broad set of phosphines including Alk3P, Alk2ArP, Ar3P and X3P was screened. Three complexes of general formula (Cymene)RuCl2PR3 were isolated in a pure form, and their catalytic activity was compared with the in situ generated complexes. Nonhindered triarylphosphines with electron acceptor groups were found to be the most perspective activating agents, increasing the activity of the catalyst approx. six times, Alk2ArP ligands have less noticeable influence, while trialkylphosphines strongly deactivate the ruthenium catalyst.
Hitchhiker's Guide to Reductive Amination
Afanasyev, Oleg I.,Chusov, Denis,Makarova, Maria,Podyacheva, Evgeniya,Tsygankov, Alexey A.
supporting information, p. 2667 - 2677 (2019/06/19)
A comparative study of various widely used methods of reductive amination is reported. Specifically, such reducing agents as H 2, Pd/C, hydride reagents [NaBH 4, NaBH 3 CN, NaBH(OAc) 3 ], and CO/Rh 2 (OAc) 4 system were considered. For understanding the selectivity and activity of the reducing agents reviewed herein, different classes of starting materials were tested, including aliphatic and aromatic amines, as well as aliphatic and aromatic aldehydes and ketones. Most important advantages and drawbacks of the methods, such as selectivity of the target amine formation and toxicity of the reducing agents were compared. Methods were also considered from the viewpoint of green chemistry.
