13260-76-9

Basic information

• Product Name: 4-phenyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
• CAS NO: 13260-76-9
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.2426
• Mol File: 13260-76-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 136°C
• Density: 1.223g/cm³
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 4-phenyl-1,4-dihydro-2H-3,1-benzoxazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-1,4-dihydro-2H-3,1-benzoxazin-2-one(13260-76-9)
• EPA Substance Registry System: 4-phenyl-1,4-dihydro-2H-3,1-benzoxazin-2-one(13260-76-9)

Safety Data

• Hazardous Substances Data: 13260-76-9(Hazardous Substances Data)

Upstream product

• 35382-88-8 N-(2-benzoylphenyl)-2,2,2-trichloroacetamide 
• 201230-82-2 carbon monoxide 
• 5176-12-5 (2-nitrophenyl)phenylmethanol 
• 56153-61-8 2-benzyl-benzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 124-38-9 carbon dioxide 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 558-13-4 carbon tetrabromide 
• 74965-34-7 tert-butyl (2-(hydroxy(phenyl)methyl)phenyl)carbamate 
• 3422-01-3 tert-butyl phenylcarbamate 
• 75-44-5 phosgene 
• 1202047-19-5 1-tert-butyl-1-isopropyl-3-phenylurea 
• 100-52-7 benzaldehyde 

Downstream Products

• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 35382-72-0 1-methyl-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 

Relevant articles and documents

Intramolecular conversion of N,N-bis(2-picolyl)ureas to cyclic carbamates

Herein, we present a new methodology for preparing 6-membered ring carbamates from a CuI-promoted cyclization of N,N-bis(2-picolyl)amine substituted ureas. The reactions work best in the presence of up to five-fold excess of CuCl at room temper

The Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- molecular insertion of hydroxyl to carbene. (Figure presented.).

From in vitro to in cellulo: Structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal molecule biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising molecule displayed anti-biofilm activity and a tight-binding mode of action. Herein, we report on the convenient synthesis and biochemical evaluation of a comprehensive series of (2-nitrophenyl)methanol derivatives. The in vitro potency of these inhibitors against recombinant PqsD as well as the effect of selected compounds on the production of the signal molecules HHQ and PQS in P. aeruginosa were examined. The gathered data allowed the establishment of a structure-activity relationship, which was used to design fluorescent inhibitors, and finally, led to the discovery of (2-nitrophenyl)methanol derivatives with improved in cellulo efficacy providing new perspectives towards the application of PqsD inhibitors as anti-infectives. This journal is the Partner Organisations 2014.