132705-51-2 Usage
Description
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate is a white to off-white powder that serves as a versatile reagent and activating agent in various chemical reactions and synthesis processes.
Uses
Used in Peptide Synthesis:
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate is used as a stable reagent for the coupling of N-Methylamino acids in peptide synthesis, facilitating the formation of peptide bonds and enhancing the overall efficiency of the process.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate is used as a coupling reagent for various applications, including:
1. Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls, which are essential components in the development of pharmaceutical compounds.
2. Functionalization of pyrimidines, synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation, using various nucleophiles to create diverse pharmaceutical compounds.
3. Synthesis of formamidines by coupling with various primary amines and N,N-diisopropylethylamine, which are important intermediates in the production of various drugs.
Used in Chemical Synthesis:
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate is also used as an activating reagent in chemical synthesis for:
1. Activation of the C-OH bond in tautomerizable heterocycles to form the phosphonium salt, which aids the Sonogashira coupling of heterocycles with various alkynes, leading to the formation of complex molecular structures.
2. One-pot activation of the C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds, which are crucial in the synthesis of various organic compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 132705-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,0 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132705-51:
(8*1)+(7*3)+(6*2)+(5*7)+(4*0)+(3*5)+(2*5)+(1*1)=102
102 % 10 = 2
So 132705-51-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
132705-51-2Relevant articles and documents
Controlled drug delivery system using the conjugation of drug to biodegradable polyester
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, (2008/06/13)
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.
Cyclic AMP-specific phosphodiesterase inhibitors
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, (2008/06/13)
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
