13290-00-1 Usage
Description
N-(2-Furoyl)glycine Methyl Ester is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its ability to be incorporated into the structure of different drugs, making it a valuable component in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Synthesis:
N-(2-Furoyl)glycine Methyl Ester is used as an intermediate in the synthesis of 2-Furoylglycine (F865225), which is an essential component in the preparation of non-nucleoside inhibitors of HCV NS5b RNA polymerase. These inhibitors play a significant role in the treatment of Hepatitis C virus (HCV) infections by targeting the viral replication process.
Additionally, N-(2-Furoyl)glycine Methyl Ester is utilized in the synthesis of benzimidazolylazabicyclooctylethylpiperidines, which are known as Ccr5 antagonists. These compounds are employed in the treatment of HIV infection by blocking the interaction between the virus and the host cells, thereby preventing the virus from entering and infecting the cells.
Used in the Chemical Industry:
N-(2-Furoyl)glycine Methyl Ester may also find applications in the chemical industry, where it can be used as a building block for the development of new compounds with potential applications in various fields, such as materials science, agriculture, and environmental science. Its versatility as a synthetic intermediate allows for the exploration of its potential in creating novel products and solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 13290-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,9 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 13290-00:
(7*1)+(6*3)+(5*2)+(4*9)+(3*0)+(2*0)+(1*0)=71
71 % 10 = 1
So 13290-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4/c1-5(8(11)12)9-7(10)6-3-2-4-13-6/h2-5H,1H3,(H,9,10)(H,11,12)
13290-00-1Relevant articles and documents
Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1
Kawaguchi, Shin-ichi,Gonda, Yuhei,Yamamoto, Takuya,Sato, Yuki,Shinohara, Hiroyuki,Kobiki, Yohsuke,Ichimura, Atsuhiko,Dan, Takashi,Sonoda, Motohiro,Miyata, Toshio,Ogawa, Akiya,Tsujita, Tadayuki
, (2018)
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect. To activate HIF exogenously, without exposing
