132929-88-5

Basic information

• Product Name: TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE
• Synonyms: (3R,5S)-1-Methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl;TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE;1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide;trans-3'-Hydroxycotinine O--D-glucuronide;trans-3-hydroxycotinine beta-D-glucuronide
• CAS NO: 132929-88-5
• Molecular Formula: C16H20N2O8
• Molecular Weight: 368.34
• Product Categories: Chiral Reagents;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Chiral Reagents, Glucuronides, Heterocycles, Metabolites & Impurities, Mutagenesis Research Chemicals;Glucuronides;Metabolites;Nicotine Derivatives
• Mol File: 132929-88-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 180-182°C
• Boiling Point: 699.2°Cat760mmHg
• Flash Point: 376.7°C
• Appearance: /
• Density: 1.58g/cm³
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• PKA: 2.78±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE(132929-88-5)
• EPA Substance Registry System: TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE(132929-88-5)

Safety Data

• Hazardous Substances Data: 132929-88-5(Hazardous Substances Data)

Usage

Description

TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE is a chemical compound that is a metabolite of nicotine, specifically identified as Nicotine (N412420). It is characterized by its chemical structure, which includes a beta-D-glucosiduronic acid that is trans-3-hydroxycotinine, where the hydroxy hydrogen is replaced by a beta-D-glucuronyl residue. TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE is known to be a carcinogen and is presented as a white solid.

Uses

Used in Pharmaceutical Research:
TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE is used as a research compound for understanding the metabolic pathways of nicotine and its potential carcinogenic effects. Its role as a metabolite helps in studying the impact of nicotine on human health and the development of smoking-related diseases.
Used in Toxicology Studies:
In the field of toxicology, TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE is used as a reference compound to investigate the toxic effects of nicotine and its metabolites on the human body. This aids in the development of strategies to mitigate the harmful effects of smoking and nicotine addiction.
Used in Chemical Analysis:
As a white solid with specific chemical properties, TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE can be used in chemical analysis to identify and quantify the presence of nicotine metabolites in various samples, such as biological fluids or environmental samples. This application is crucial for monitoring exposure to nicotine and its potential health risks.
Used in Drug Development:
TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE may also be utilized in the development of new drugs or therapies targeting nicotine addiction and related health issues. Understanding the metabolic pathways and toxic effects of nicotine can lead to the creation of more effective treatments for smoking cessation and the prevention of smoking-related diseases.