13296-21-4

Basic information

• Product Name: Carbamic acid, [3-[(4S)-2,5-dioxo-4-oxazolidinyl]propyl]-, phenylmethyl ester
• CAS NO: 13296-21-4
• Molecular Formula: C14H16N2O5
• Molecular Weight: 292.291
• Mol File: 13296-21-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-[(4S)-2,5-dioxo-4-oxazolidinyl]propyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-[(4S)-2,5-dioxo-4-oxazolidinyl]propyl]-, phenylmethyl ester(13296-21-4)
• EPA Substance Registry System: Carbamic acid, [3-[(4S)-2,5-dioxo-4-oxazolidinyl]propyl]-, phenylmethyl ester(13296-21-4)

Safety Data

• Hazardous Substances Data: 13296-21-4(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 16937-91-0 N^ε-(benzyloxycarbonyl)ornithine 
• 501-53-1 benzyl chloroformate 
• 3184-13-2 L-ornithine hydrochloride 
• 141-78-6 ethyl acetate 
• 2274-58-0 (S)-2,5-bis-(benzyloxycarbonylamino)pentanoic acid 

Downstream Products

• 54745-14-1 {3-[(S)-3-(2-nitro-phenylsulfanyl)-2,5-dioxo-oxazolidin-4-yl]-propyl}-carbamic acid benzyl ester 

Relevant articles and documents

Guanidinated multi-arm star polyornithines with a polyethylenimine core for gene delivery

Multi-arm star polyornithines PEI-P(Orn)n are prepared by grafting polyornithine arms onto branched polyethylenimine (PEI) with an M w of 600 via the ring-opening polymerization of N-carboxyanhydride of benzyloxycarbonyl ornithine. To enhance gene delivery efficiency and reduce cytotoxicity, the amino side groups on the polyornithine arms are partially guanidinated that transforms the ornithine units to arginine units. Thus, the guanidinated products G-PEI-P(Orn)n contain multiple poly(ornithine-co-arginine) arms. PEI-P(Orn)n and G-PEI-P(Orn) 71 mediate the transfection of pGL3 plasmid to 293T cells almost as efficient as 25 kDa PEI in serum-free medium. Notably, in contrast to the dramatically lowered efficiency of 25 kDa PEI in the presence of serum, the efficiency of G-PEI-P(Orn)71 can be retained or even enhanced in the medium containing 10% serum. The improved serum-compatibility and high efficiency of the guanidinium-modified star polyornithines make them promising for gene delivery.