133029-32-0

Basic information

• Product Name: POLYAMINOPROPYL BIGUANIDE
• Synonyms: POLYAMINOPROPYL BIGUANIDE;N-(3-Aminopropyl)imidodicarbonimidic diamide homopolymer;POLYAMINE PROPYL BIGUANIDE;Polyaminopropyl biguanide, PAPB
• CAS NO: 133029-32-0
• Molecular Formula: (C5H14N6)x
• Molecular Weight: 158.21
• Mol File: 133029-32-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: POLYAMINOPROPYL BIGUANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: POLYAMINOPROPYL BIGUANIDE(133029-32-0)
• EPA Substance Registry System: POLYAMINOPROPYL BIGUANIDE(133029-32-0)

Safety Data

• Hazardous Substances Data: 133029-32-0(Hazardous Substances Data)

Usage

Description

POLYAMINOPROPYL BIGUANIDE, also known as polyhexamethylene biguanide (PHMB), is a hydrochloride salt with broad-spectrum and fast-acting bactericidal properties. It is widely recognized for its antiviral and antibacterial characteristics, making it a valuable component in the formulation of disinfectants and sanitizers.

Uses

Used in Healthcare Industry:
POLYAMINOPROPYL BIGUANIDE is used as an antiseptic agent for wound care dressings, providing effective protection against bacterial and viral infections, promoting faster healing and reducing the risk of complications.
Used in Optometry:
In the field of optometry, POLYAMINOPROPYL BIGUANIDE is used as a cleaning agent for contact lens solutions, ensuring the lenses are free from harmful microorganisms and maintaining eye health.
Used in Medical Procedures:
POLYAMINOPROPYL BIGUANIDE is utilized as a perioperative cleansing agent, helping to minimize the risk of infection during and after surgical procedures by effectively eliminating bacteria and viruses from the skin.
Used in Recreational Facilities:
In swimming pools, POLYAMINOPROPYL BIGUANIDE is used as a sanitizer, maintaining water quality and safety by controlling the growth of harmful microorganisms, thus providing a hygienic environment for swimmers.
Used in Disinfectant and Sanitizer Formulation:
POLYAMINOPROPYL BIGUANIDE is used as an active ingredient in the formulation of disinfectants and sanitizers, offering broad-spectrum protection against various bacteria and viruses, ensuring cleanliness and reducing the spread of infections in various settings.

Side effects

PHMB (polyaminopropyl biguanide) proved toxic to keratocytes and was shown to have acute toxic effects in human cells where it caused severe inflammation, atherogenesis, and aging.

Safety

Polyaminopropyl Biguanide (PHMB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories.

Related news

CommentaryOpinion of the scientific committee on consumer safety (SCCS) – 2nd Revision of the safety of the use of poly(hexamethylene) biguanide hydrochloride or POLYAMINOPROPYL BIGUANIDE (cas 133029-32-0) (PHMB) in cosmetic products09/02/2019

Conclusion of the opinion: On the basis of the data available, the SCCS concludes that Polyaminopropyl Biguanide (PHMB) is not safe for consumers when used as a preservative in cosmetic spray formulations and in all cosmetic products up to the maximum concentration of 0.3%. The safe use could be...detailed