1330736-74-7

Basic information

• Product Name: ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate
• CAS NO: 1330736-74-7
• Molecular Weight: 429.43
• Mol File: 1330736-74-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate(1330736-74-7)
• EPA Substance Registry System: ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate(1330736-74-7)

Safety Data

• Hazardous Substances Data: 1330736-74-7(Hazardous Substances Data)

Upstream product

• 1330736-76-9 ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate 
• 747414-22-8 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide 
• 126085-91-4 5-tributylstannanyl-isoxazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity

A series of isosteric surrogates of the 4-phenyl group in luminespib were investigated as new scaffolds of the Hsp90 inhibitor for the discovery of novel antitumor agents. Among the synthesized surrogates of isoxazole and pyrazole, compounds 4a, 5e and 12b exhibited potent Hsp90 inhibition in ATPase activity and Her2 degradation assays and significant antitumor activity in A2780 and HCT116 cell lines. Animal studies indicated that compared to luminespib, their activities were superior in A2780 or NCI-H1975 tumor xenograft models. A molecular modeling study demonstrated that compound 4a could fit nicely into the N-terminal ATP binding pocket.