133088-86-5

Basic information

• Product Name: Methanone, bis[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
• CAS NO: 133088-86-5
• Molecular Formula: C23H26O5
• Molecular Weight: 382.456
• Mol File: 133088-86-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, bis[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, bis[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(133088-86-5)
• EPA Substance Registry System: Methanone, bis[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(133088-86-5)

Safety Data

• Hazardous Substances Data: 133088-86-5(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 611-99-4 4,4'-Dihydroxybenzophenone 

Downstream Products

• 137743-24-9 2-[4-(2-Diethylamino-ethoxy)-phenyl]-3,3-bis-(4-hydroxy-phenyl)-acrylonitrile 

Relevant articles and documents

IMINO ETHER DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT

The compound represented by formula (I) (wherein R1 and R2 are cyclic group which may have a substituent(s) and so on.; W is a spacer of which main chain has an atom number of 1-6.; X is -O- and so on.; ringA is cyclic group which may have a substituent(s).; Y is a spacer of which main chain has an atom number of 1-6 and so on.; Z is acidic group.) a salt thereof, a solvent thereof or an N-oxide thereof or a prodrug thereof Since the compounds in the present invention have a regulatory activity for peroxisome proliferator activated receptor, the compounds in the present invention are useful as a preventive and/or therapeutic agent for diseases associating metabolic disorders (e.g., hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipidemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or a VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or metabolic syndrom.

Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation

The response profiles of 36 para-substituted diphenylethylenes (DPEs) and triphenylacrylonitriles (TPEs) have been compared by multivariate analysis. The responses measured were (a) relative binding affinity (RBA) for the cytosol estrogen receptor (ER), (