133101-74-3Relevant articles and documents
Substrate-Dependent Electrochemical Dimethoxylation of Olefins
Zhang, Sheng,Li, Lijun,Wu, Ping,Gong, Pengjuan,Liu, Rui,Xu, Kun
, p. 485 - 489 (2019)
A general and direct electrochemical dimethoxylation of olefins is reported, which enables a divergent route to different products depending on the structure of olefins. The present protocol features mild conditions and broad substrate scope (49 examples) obviating the usage of transtion-metals and external oxidants. More importantly, to rationalize the divergent route of the transformation, an ionic-like pathway involving carbocation intermediate is proposed and the diverse products is attributed to the different stability of carbocations. (Figure presented.).
Stereoselective Reduction of γ-Oxobutanoic Acids Using DIBAL-H and ZnCl2
Frenette, R.,Monette, M.,Bernstein, M. A.,Young, R. N.,Verhoeven, T. R.
, p. 3083 - 3089 (2007/10/02)
A variety of γ-aromatic γ-ketobutanoic acids can be reduced selectively, under optimized conditions, by the use of DIBAL-H and ZnCl2 to provide the (RS,SR)-γ-aryl-γ-hydroxy-β-methylbutanoic acids.Further evidence has been gathered to support the hypothesis that the reaction proceeds by formation of a seven-membered ring complex with the aluminium or zinc atom bridging the ketone and carboxyl groups which preceeds the reduction step and that this templated reduction accounts for observed high diastereoselectivity.Also we have shown that some γ-aryl-γ-butyrolactones can be easily transformed via an oxidative cleavage of the aromatic ring to provide selective synthesis of either cis- or trans-tetrahydro-3-methyl-5-oxo-2-furancarboxylic acid derivatives.
