133129-56-3

Basic information

• Product Name: Benzene, 1,2-dimethoxy-4-(methoxymethoxy)-
• CAS NO: 133129-56-3
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Mol File: 133129-56-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 1,2-dimethoxy-4-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,2-dimethoxy-4-(methoxymethoxy)-(133129-56-3)
• EPA Substance Registry System: Benzene, 1,2-dimethoxy-4-(methoxymethoxy)-(133129-56-3)

Safety Data

• Hazardous Substances Data: 133129-56-3(Hazardous Substances Data)

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 13057-17-5 bromethyl methyl ether 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 169776-14-1 1-bromo-4,5-dimethoxy-2-(methoxymethoxy)benzene 
• 1003858-36-3 2-(6'-hydroxy-2',3'-dimethoxyphenyl)-6-hydroxy-7-methoxybenzofuran 
• 1266622-06-3 2-iodo-3,4-dimethoxy-1-(methoxymethoxy)benzene 
• 1266622-08-5 4-(2,3-dimethoxy-6-(methoxymethoxy)phenyl)-2-methylbut-3-yn-2-ol 
• 1266622-10-9 2-ethynyl-3,4-dimethoxy-1-(methoxymethoxy)benzene 
• 1266622-12-1 C₁₉H₂₀O₇ 
• 1376220-15-3 (3,4-dimethoxy-2-methylphenoxy)methyl methyl ether 
• 113296-70-1 2-benzyloxy-4,5-dimethoxy-3-methylbenzaldehyde 
• 50827-64-0 3,4-dimethyoxy-2-methylphenol 
• 1332271-54-1 C₁₉H₂₂O₆ 
• 1332271-09-6 C₁₉H₂₄O₅ 
• 1332271-53-0 C₃₈H₃₈O₅ 
• 1332271-52-9 C₃₇H₃₆O₅ 
• 1332271-08-5 C₁₈H₂₂O₅ 

Relevant articles and documents

Studies toward the total synthesis of popolohuanone E: enantioselective synthesis of 8-O-methylpopolohuanone E.

[structure: see text]. 8-O-methylpopolohuanone E (2) was synthesized in a highly convergent manner starting from the cis-fused decalin derivative accessible from the (-)-Wieland-Miescher ketone analogue. The synthetic method features a biogenetic-type annulation of the phenolic and quinone segments to regioselectively construct the central tricyclic ring system as the key step.

Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant

A series of A-ring-modified lamellarin N analogues were designed, synthesized, and evaluated as potential noncovalent inhibitors of the EGFR T790M/L858R mutant, a causal factor in the drug-resistant non-small cell lung cancer. Several water-soluble ammonium- or guanidinium-tethered analogues exhibited good kinase inhibitory activities. The most promising analogue, 14f, displayed an excellent inhibitory profile against the T790M/L858R mutant [IC50 (WT) = 31.8 nM; IC50 (T790M/L858R) = 8.9 nM]. The effects of A-ring-substituents on activity were rationalized by docking studies.

Chemistry of renieramycins. Part 12: An improved total synthesis of (±)-renieramycin G

An improved total synthesis of (±)-renieramycin G (1g) from readily available 2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde (7) in 21 steps (6.3% overall yield) is described. The synthesis features the concise construction of a pentacyclic framework using the stereoselective Pictet-Spengler type cyclization reaction of lactam (25) with ethyl diethoxyacetate, followed by the base-catalyzed epimerization of the C-1 stereo center of aldehyde (30a). The results of cytotoxicity studies are also presented.