133156-35-1Relevant articles and documents
Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells
Park, Eun-Jung,Min, Hye-Young,Ahn, Yong-Hyun,Bae, Cheol-Man,Pyee, Jae-Ho,Lee, Sang Kook
, p. 5895 - 5898 (2007/10/03)
The inhibitory effects of pinosylvin analogues on the production of COX-2 mediated PGE2 were evaluated in a cell culture system. A new series of potential inhibitors, including 3-hydroxy-5-benzyloxy-trans-stilbene and 3,5-dimethoxy-trans-stilbene, have been identified. A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.