133205-43-3

Basic information

• Product Name: 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine
• Synonyms: 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine
• CAS NO: 133205-43-3
• Molecular Weight: 203.308
• Mol File: 133205-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine(133205-43-3)
• EPA Substance Registry System: 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine(133205-43-3)

Safety Data

• Hazardous Substances Data: 133205-43-3(Hazardous Substances Data)

Upstream product

• 103-79-7 1-phenyl-acetone 
• 31357-83-2 3-chloro-2-phenyl-but-2-enal 
• 60-23-1 Cysteamine 
• 156-57-0 2-mercaptoethylamine hydrochloride 

Relevant articles and documents

Synthesis and reactivity of 3-chloro-3-trifluoromethylacroleins: stabilisation of the tetrahedral intermediate in a nucleophilic vinylic "substitution"

Trifluoromethyl ketones 1a-d reacted with the Vilsmeier reagent to give CF3-substituted β-chloro-vinylaldehydes 2a-d in good yields.Using 2-amino-ethanethiol as a nucleophile, a different regiochemistry of cyclization that depends on a methyl or trifluoromethyl substituent was observed.The cyclization of trifluoromethyl compounds 2a and 2e into thiazolidines 7 or 24 results in the stabilization of the tetrahedral intermediate by the captodative effect.We report the first direct substitution of a tetrahedral intermediate (instead of elimination) in a nucleophilic vinylic reaction. trifluoromethylacroleins / Michael addition / tetrahedral intermediate