1332481-73-8Relevant articles and documents
Palladium-catalyzed alkylation of ortho-C(sp2)-H bonds of benzylamide substrates with alkyl halides
Zhao, Yingsheng,Chen, Gong
, p. 4850 - 4853 (2011/11/06)
A highly efficient and generally applicable method has been developed to functionalize the ortho-C(sp2)-H bonds of picolinamide (PA)-protected benzylamine substrates with a broad range of β-H-containing alkyl halides. Sodium triflate has been identified as a critical promoter for this reaction system. The PA group can be easily installed and removed under mild conditions. This method provides a new strategy to prepare highly functionalized benzylamines for the synthesis of complex molecules.