1332493-26-1Relevant articles and documents
Pyrimidinone nicotinamide mimetics as selective tankyrase and Wnt pathway inhibitors suitable for in vivo pharmacology
Johannes, Jeffrey W.,Almeida, Lynsie,Barlaam, Bernard,Boriack-Sjodin, P. Ann,Casella, Robert,Croft, Rosemary A.,Dishington, Allan P.,Gingipalli, Lakshmaiah,Gu, Chungang,Hawkins, Janet L.,Holmes, Jane L.,Howard, Tina,Huang, Jian,Ioannidis, Stephanos,Kazmirski, Steven,Lamb, Michelle L.,McGuire, Thomas M.,Moore, Jane E.,Ogg, Derek,Patel, Anil,Pike, Kurt G.,Pontz, Timothy,Robb, Graeme R.,Su, Nancy,Wang, Haiyun,Wu, Xiaoyun,Zhang, Hai-Jun,Zhang, Yue,Zheng, Xiaolan,Wang, Tao
, p. 254 - 259 (2015)
The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and ?-catenin, can lead to oncogenesis. Inhibition of the poly(ADP-r
Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles
Holmes, Jane L.,Almeida, Lynsie,Barlaam, Bernard,Croft, Rosemary A.,Dishington, Allan P.,Gingipalli, Laksmaiah,Hassall, Lorraine A.,Hawkins, Janet L.,Ioannidis, Stephanos,Johannes, Jeffrey W.,McGuire, Thomas M.,Moore, Jane E.,Patel, Anil,Pike, Kurt G.,Pontz, Timothy,Wu, Xiaoyun,Wang, Tao,Zhang, Hai-Jun,Zheng, Xiaolan
supporting information, p. 1226 - 1234 (2016/05/19)
Examples of hydroxymethylated analogues of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones are sparse or non-existent in the scientific literature. We have demonstrated that such compounds are accessible by using standard procedures from readily available raw materials.
