133262-42-7Relevant articles and documents
N-ACRYLOYLPIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PAF ANTAGONISTS
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, (2008/06/13)
Compounds of formula (I): STR1 wherein R 1 and R 2 is each--R 5,--CH=CH--R 5 or--C C--R 5, wherein R. sup.5 is optionally substituted aryl or aromatic heterocyclic; R 3 is hydrogen, alkyl, cyano or--R 5 ; X is oxygen or sulfur; A is 1,4-piperazin-1, 4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R 4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecular with a compound containing the other part of the molecule.