1333113-25-9Relevant articles and documents
Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors
Zhao, Wen Jing,Shi, Yong Heng,Zhao, Gui Long,Wang, Yu Li,Shao, Hua,Da Tang, Li,Wang, Jian Wu
scheme or table, p. 1215 - 1218 (2012/02/02)
A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.