1333334-64-7

Basic information

• Product Name: 1-(4-fluorophenyl)-3-ethoxycarbonyl-5-(2-pyrrolyl)-1,2,4-triazole
• Synonyms: 1-(4-fluorophenyl)-3-ethoxycarbonyl-5-(2-pyrrolyl)-1,2,4-triazole
• CAS NO: 1333334-64-7
• Molecular Weight: 300.292
• Mol File: 1333334-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-3-ethoxycarbonyl-5-(2-pyrrolyl)-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-3-ethoxycarbonyl-5-(2-pyrrolyl)-1,2,4-triazole(1333334-64-7)
• EPA Substance Registry System: 1-(4-fluorophenyl)-3-ethoxycarbonyl-5-(2-pyrrolyl)-1,2,4-triazole(1333334-64-7)

Safety Data

• Hazardous Substances Data: 1333334-64-7(Hazardous Substances Data)

Upstream product

• 37522-19-3 [(4-fluorophenyl)-hydrazono]-chloroacetic acid ethyl ester 
• 32597-34-5 1H-pyrrole-2-carbaldehyde oxime 

Relevant articles and documents

Synthesis and antiproliferative evaluation of 3,5-disubstituted 1,2,4-triazoles containing flurophenyl and trifluoromethanephenyl moieties

An efficient 1,3-dipolar cycloaddition method was performed for the synthesis of a series of monofluoro- and trifluoromethane-3,5-disubstituted 1,2,4-triazoles. This efficient cycloaddition method was to react hydrazonoyl hydrochlorides with a series of aldehydes in the presence of NEt3 as catalytic basic agent to provide the corresponding product in 28-94%. Their growth inhibitory results against cancer cells indicated that some of the fluorine- and trifluoromethane-containing compounds could effectively inhibit the growth of NCI-H226 and T-cell leukemia (Jurkat) cells. Among the compounds, trifluoromethane-containing 1,2,4-triazoles possessed the five-membered ring groups on the C-5 position of the triazolic ring, including cyclopentyl, 3-furyl, 3-thienyl, and 2-pyrrolyl, possessed the significant inhibitory activity for NCI-H226 cancer cells.