1333529-95-5

Basic information

• Product Name: 5-(2-nitrophenyl)-1,5-dihydro-2H,2’H-spiro{furo[2,3-d]pyrimidine-6,5’-pyrimidine}-2,2’,4,4’,6’(1’H,3H,3’H)-pentone
• Synonyms: 5-(2-nitrophenyl)-1,5-dihydro-2H,2’H-spiro{furo[2,3-d]pyrimidine-6,5’-pyrimidine}-2,2’,4,4’,6’(1’H,3H,3’H)-pentone
• CAS NO: 1333529-95-5
• Molecular Weight: 387.265
• Mol File: 1333529-95-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(2-nitrophenyl)-1,5-dihydro-2H,2’H-spiro{furo[2,3-d]pyrimidine-6,5’-pyrimidine}-2,2’,4,4’,6’(1’H,3H,3’H)-pentone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-nitrophenyl)-1,5-dihydro-2H,2’H-spiro{furo[2,3-d]pyrimidine-6,5’-pyrimidine}-2,2’,4,4’,6’(1’H,3H,3’H)-pentone(1333529-95-5)
• EPA Substance Registry System: 5-(2-nitrophenyl)-1,5-dihydro-2H,2’H-spiro{furo[2,3-d]pyrimidine-6,5’-pyrimidine}-2,2’,4,4’,6’(1’H,3H,3’H)-pentone(1333529-95-5)

Safety Data

• Hazardous Substances Data: 1333529-95-5(Hazardous Substances Data)

Upstream product

• 67-52-7 BARBITURIC ACID 
• 99-61-6 3-nitro-benzaldehyde 

Relevant articles and documents

Molecular iodine-catalysed tandem synthesis of oxospirotricyclic furopyrimidines in water

A simple, efficient and high yielding one-pot protocol for the synthesis of oxospirotricyclic furobarbiturates was developed by pseudo three-component domino coupling of barbituric acids and various benzaldehydes in water, catalysed by molecular iodine.

New strategy for the synthesis of 5-Aryl-1H,1′H-spiro[furo[2,3-d] pyrimidine-6,5′-pyrimidine]2,2′,4,4′,6′(3H,3'H,5H) -pentaones and their sulfur analogues

Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and aldehydes in the presence of L-(+)-tartaric acid afforded a new route for the synthesis of stable heterocyclic 5-aryl-1H,1′H-spiro[furo[2,3-d]pyrimidine-6,5′- pyrimidine]2,2′,4,4′,6′(3H,3′H,5H)- pentaones which is a dimeric form of barbiturate (uracil and thiouracil derivative). In the reaction of 1,3-diethyl thiobarbituric acid (DETBA) the Knoevenagel condensation and then Michael adducts were obtained under the same condition. Structure elucidation is carried out by 1H NMR, 13C NMR, FT-IR and Mass analyses. Mechanism of the formation is discussed.