13339-02-1

Basic information

• Product Name: 2-PIPERAZIN-1-YL-PHENYLAMINE
• Synonyms: 2-PIPERAZIN-1-YL-PHENYLAMINE;2-PIPERAZIN-1-YLANILINE;Benzenamine, 2-(1-piperazinyl)- (9CI);2-Piperazin-1-ylaniline 95%;2-(1-Piperazino)aniline, 95%;2-(1-Piperazinyl)aniline, 95%;2-(Piperazin-1-yl)benzenamine;1-(2-AMinophenyl)piperazine
• CAS NO: 13339-02-1
• Molecular Formula: C₁₀H₁₅N₃
• Molecular Weight: 177.25
• Product Categories: PIPERIDINE
• Mol File: 13339-02-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 344.846 °C at 760 mmHg
• Flash Point: 162.358 °C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-PIPERAZIN-1-YL-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERAZIN-1-YL-PHENYLAMINE(13339-02-1)
• EPA Substance Registry System: 2-PIPERAZIN-1-YL-PHENYLAMINE(13339-02-1)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 13339-02-1(Hazardous Substances Data)

Usage

General Description

2-PIPERAZIN-1-YL-PHENYLAMINE is a chemical compound with the molecular formula C12H17N3. It is a phenylamine derivative that contains a piperazine ring. This chemical is commonly used in the pharmaceutical industry for the synthesis of various drugs and medication. It has been studied for its potential therapeutic applications, including its use as an antipsychotic and anti-anxiety agent. Additionally, 2-PIPERAZIN-1-YL-PHENYLAMINE has been investigated for its potential role in the treatment of depression and other mood disorders. Its unique chemical structure and pharmacological properties make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C10H15N3/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8,11H2

Upstream product

• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 
• 95-54-5 1,2-diamino-benzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 59084-06-9 1-(2-nitrophenyl)piperazine 

Downstream Products

• 960203-27-4 Vortioxetine hydrobromide 
• 508233-74-7 vortioxetine 

Relevant articles and documents

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.

Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

A series of 2′-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 μM) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 μM) and as such, serves as a lead candidate for further optimization studies.