133391-63-6 Usage
General Description
3-nitro-2-(trifluoromethyl)pyridine is a chemical compound with the formula C6H3F3N2O2. It is a yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a highly reactive compound due to the presence of the nitro group, which makes it useful in various chemical reactions. The trifluoromethyl group also adds to its reactivity and electronic properties, making it a valuable building block in organic chemistry. However, it should be handled with caution due to its potentially hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 133391-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,3,9 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 133391-63:
(8*1)+(7*3)+(6*3)+(5*3)+(4*9)+(3*1)+(2*6)+(1*3)=116
116 % 10 = 6
So 133391-63-6 is a valid CAS Registry Number.
InChI:InChI=1S/C6H3F3N2O2/c7-6(8,9)5-4(11(12)13)2-1-3-10-5/h1-3H
133391-63-6Relevant articles and documents
Synthesis method of 3-fluoro-2-trifluoromethyl isonicotinic acid
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Paragraph 0020-0023, (2020/01/12)
The invention discloses a synthesis method of a fluorine-containing heterocyclic compound medical intermediate. The method comprises the following steps: (1) taking 2-chloro-3-nitropyridine as a raw material to carry out reacting with trifluoromethyltrimethylsilane in dimethyl formamide (DMF) under catalysis of cuprous iodide and 1,10-phenanthroline to obtain 2-trifluoromethyl-3-nitropyridine; (2)carrying out a reflux reaction on the obtained 2-trifluoromethyl-3-nitropyridine in tetrabutylammonium fluoride by using acetonitrile, dimethyl sulfoxide (DMSO) or DMF as a solvent to obtain 2-trifluoromethyl-3-fluoropyridine; and (3) removing hydrogen from the obtained 2-trifluoromethyl-3-fluoropyridine under action of a lithium reagent, and introducing dry carbon dioxide gas to obtain the 3-fluoro-2-trifluoromethyl isonicotinic acid. The method has the advantages of high product yield, high operability, environmental friendliness, high safety factor and the like.
