1334001-49-8Relevant articles and documents
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
Mazur, Marzena,Olczak, Jacek,Olejniczak, Sylwia,Koralewski, Robert,Czestkowski, Wojciech,Jedrzejczak, Anna,Golab, Jakub,Dzwonek, Karolina,Dymek, Barbara,Sklepkiewicz, Piotr L.,Zagozdzon, Agnieszka,Noonan, Tom,Mahboubi, Keyvan,Conway, Bruce,Sheeler, Ryan,Beckett, Paul,Hungerford, William M.,Podjarny, Alberto,Mitschler, Andre,Cousido-Siah, Alexandra,Fadel, Firas,Golebiowski, Adam
, p. 695 - 710 (2018/02/17)
This article highlights our work toward the identification of a potent, selective, and efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led
Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy
Gao, Zhongli,Hurst, William J.,Hall, Daniel,Hartung, Ryan,Reynolds, William,Kang, Jiesheng,Nagorny, Raisa,Hendrix, James A.,George, Pascal G.
, p. 429 - 438 (2015/01/30)
Lead compounds 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenyl]-benzamide (1), tetrahydro-pyran-4-carboxylic acid [((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenyl]-amide (2), and 3,5-dimethyl-isoxazole-4-carboxylic acid
