1334215-69-8Relevant articles and documents
Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents
Guo, Hao,Zhang, Guolan,Zhang, Tao,He, Xianran,Wu, Zhongyuan,Xiao, Yuling,Pan, Yuanhu,Qiu, Guofu,Liu, Peng,Hu, Xianming
, p. 3662 - 3674 (2011/11/05)
A series of new 16β-azolyl-3β-amino-5α-androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activity against the human cancer cell lines SW480, A549, HepG2, HeLa and SiHa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC50 values lower than 20 μM against the five cancer cell lines.