1334219-14-5Relevant articles and documents
CoA adducts of 4-oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis menaquinone biosynthesis pathway
Li, Xiaokai,Liu, Nina,Zhang, Huaning,Knudson, Susan E.,Li, Huei-Jiun,Lai, Cheng-Tsung,Simmerling, Carlos,Slayden, Richard A.,Tonge, Peter J.
supporting information; experimental part, p. 818 - 823 (2012/01/06)
A high-throughput screen led to the discovery of 2-amino-4-oxo-4- phenylbutanoate inhibitors of the 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) from the menaquinone biosynthesis pathway in Mycobacterium tuberculosis. However, these compounds are unstabl