1334312-52-5

Basic information

• Product Name: MK-8325
• Synonyms: MK-8325
• CAS NO: 1334312-52-5
• Molecular Weight: 843.018
• Mol File: 1334312-52-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: MK-8325(CAS DataBase Reference)
• NIST Chemistry Reference: MK-8325(1334312-52-5)
• EPA Substance Registry System: MK-8325(1334312-52-5)

Safety Data

• Hazardous Substances Data: 1334312-52-5(Hazardous Substances Data)

Upstream product

• 1612854-21-3 C₁₈H₂₀BrF₂NO₅ 
• 203866-15-3 1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline 
• 111398-44-8 N-methoxycarbonyl-L-valine 
• 268224-29-9 (R)-3,3-dimethyl-[1,3]azasilolidine-1,5-dicarboxylic acid 1-tert-butyl ester 
• 268224-27-7 (R)-1-tert-butyl-5-methyl 3,3-dimethyl-1,3-azasilolidine-1,5-dicarboxylate 
• 1334313-65-3 (2R,5R)-2-[(chloromethyl-dimethyl-silanyl)-methyl]-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 1241377-74-1 6-bromo-naphthalene-1,2-diamine 
• 1309945-25-2 C₁₀H₇BrN₂O₂*ClH 
• 855930-17-5 N-acetyl-1-nitro-6-bromonaphthalene 
• 71590-32-4 N-(6-bromo-[2]naphthyl)-acetamide 
• 5773-80-8 6-bromo-2-naphthoic acid 
• 71590-31-3 6-bromo-2-aminonaphthalene hydrochloride 
• 1007882-13-4 (S)-tert-butyl 4,4-difluoro-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate 
• 1007882-05-4 (S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4,4-difluoropyrrolidine-1-carboxylate 

Relevant articles and documents

MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV

HCV NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays thus making them attractive components for inclusion in an all oral fixed dose combination regimen. Herein, we describe the discovery and characterization of silyl proline-containing HCV NS5A inhibitor MK-8325 with good pan-genotype activity and acceptable pharmacokinetic properties.