133455-43-3

Basic information

• Product Name: trans-ethyl-(2-chloro)-α-methylcinnamate
• CAS NO: 133455-43-3
• Molecular Weight: 224.687
• Mol File: 133455-43-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: trans-ethyl-(2-chloro)-α-methylcinnamate(CAS DataBase Reference)
• NIST Chemistry Reference: trans-ethyl-(2-chloro)-α-methylcinnamate(133455-43-3)
• EPA Substance Registry System: trans-ethyl-(2-chloro)-α-methylcinnamate(133455-43-3)

Safety Data

• Hazardous Substances Data: 133455-43-3(Hazardous Substances Data)

Upstream product

• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1614-98-8 3-(2-chlorophenyl)-2-methylacrylic acid 
• 51220-02-1 (E)-3-(2-chlorophenyl)-2-methylacrylonitrile 

Relevant articles and documents

Highly efficient Rh-catalyzed asymmetric hydrogenation of α,β-unsaturated nitriles

A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).

Acyl guanidine sodium/proton exchange inhibitors and method

Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure STR1 wherein n is 1 to 5; X is N or C--R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.