1335096-75-7

Basic information

• Product Name: (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid
• Synonyms: (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid
• CAS NO: 1335096-75-7
• Molecular Weight: 296.323
• Mol File: 1335096-75-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid(1335096-75-7)
• EPA Substance Registry System: (2E)-3-{4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}prop-2-enoic acid(1335096-75-7)

Safety Data

• Hazardous Substances Data: 1335096-75-7(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 121-33-5 vanillin 
• 1122-91-4 4-bromo-benzaldehyde 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 34633-09-5 3-(p-iodophenyl)acrylic acid 
• 7786-61-0 3-methoxy-4-hydroxystyrene 

Relevant articles and documents

Pd-catalyzed orthogonal Knoevenagel/Perkin condensation-decarboxylation- heck/Suzuki sequences: Tandem transformations of benzaldehydes into hydroxy-functionalized antidiabetic stilbene-cinnamoyl hybrids and asymmetric distyrylbenzenes

Tandem reactions that involve chemoselective Knoevenagel/Perkin condensation-decarboxylation-Heck/Suzuki coupling or Heck-aldol sequences have been achieved. This enabled the first concise and efficient synthesis of several important hydroxy-functionalized compound classes, such as stilbene-cinnamoyl hybrids (potent protein tyrosine phosphatase1B inhibitors), cinnamoyl-cinnamic acid hybrids, asymmetric distyrylbenzenes, and biarylstyrenes. Previously reported synthesis require multiple steps and protection/deprotection manipulations.