1335545-32-8Relevant articles and documents
Lipase catalyzed resolution of the quaternary stereogenic center in ketone-derived benzo-fused cyclic cyanohydrins
Rodriguez-Rodriguez, Jesus A.,Gotor, Vicente,Brieva, Rosario
, p. 1218 - 1224 (2011)
The enantioselective preparation of both enantiomers of the benzo-fused cyanohydrin derived from atetralone via lipase catalyzed processes is described. The (S)-enantiomer has been obtained as the remaining substrate in the CAL-A catalyzed aminolysis of the methoxyacetylated derivative, using a structurally related amine as the nucleophile. The (R)-enantiomer has been obtained as the product of CAL-A or PSL-C catalyzed hydrolysis of the methoxyacetylated derivative in organic solvents. The resolutions of several structural analogs of this cyanohydrin have been also tested under similar conditions.