133613-71-5 Usage
Description
Galiellalactone is a fungal metabolite derived from the ascomycetes G. rufa strain A75-86 and A111-95. It is known for its ability to inhibit IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM. Galiellalactone selectively blocks the binding of activated STAT3 dimers to their DNA binding sites without affecting the phosphorylation of the STAT3 transcription factor. It exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, making it a potential therapeutic approach to control JAK/STAT signaling.
Uses
Used in Pharmaceutical Industry:
Galiellalactone is used as a STAT3 inhibitor for its ability to block the binding of activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. This selective inhibition makes it a promising compound for the development of future prostate cancer drugs.
Used in Cancer Research:
Galiellalactone is used as a research tool to study the role of STAT3 in cancer cell growth and proliferation. Its ability to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM makes it a valuable asset in understanding the underlying mechanisms of cancer development and progression.
Used in Drug Development:
Galiellalactone is used as a starting point for the development of new drugs targeting STAT3-mediated signaling pathways. Its selectivity and potency in inhibiting STAT3 dimer binding to DNA make it a promising candidate for the creation of novel therapeutics for various types of cancer, including prostate cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 133613-71-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,1 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133613-71:
(8*1)+(7*3)+(6*3)+(5*6)+(4*1)+(3*3)+(2*7)+(1*1)=105
105 % 10 = 5
So 133613-71-5 is a valid CAS Registry Number.
133613-71-5Relevant articles and documents
Diastereoselective Total Synthesis of (-)-Galiellalactone
Kim, Taewoo,Han, Young Taek,An, Hongchan,Kim, Kyeojin,Lee, Jeeyeon,Suh, Young-Ger
, p. 12193 - 12200 (2015)
An enantioselective total synthesis of (-)-galiellalactone has been accomplished. The key features of the synthesis involve the highly stereoselective construction of the cis-trisubstituted cyclopentane intermediate by a Pd(0)-catalyzed cyclization, the stereospecific introduction of an angular hydroxyl group by Riley oxidation, and the efficient construction of the tricyclic system of (-)-galiellalactone via a combination of diastereoselective Hosomi-Sakurai crotylation and ring-closing metathesis (RCM)
Synthesis of (-)-galiellalactone
Johansson, Martin,Sterner, Olov
, p. 663 - 665 (2007/10/03)
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