133645-46-2Relevant articles and documents
COMPOUND, AND SEPARATION METHOD, SYNTHESIS METHOD AND USE THEREOF
-
Paragraph 0178-0179, (2018/02/28)
The invention relates to new compounds as well as a separation method, a synthetic method and use thereof. It is demonstrated by an assay on activity that the compound has an activity of inhibiting an HMG-CoA reductase. In addition, the invention also relates to a derivative of the compound.
Autooxidation of simvastatin
Smith,DiMichele,Colwell Jr.,Dezeny,Douglas,Reamer,Verhoeven
, p. 4447 - 4462 (2007/10/02)
Autooxidation of the cholesterol-lowering agent simvastatin in ethylene dichloride solution with an azo-type free-radical initiator was investigated in kinetic studies using HPLC. The primary products were oligomers, with peroxide groups within the backbone chain, and some monomeric epoxides. These and several secondary products were isolated chromatographically and identified spectroscopically. A reaction scheme was proposed in which the oligomers arise from competitive hydrogen abstraction and addition reactions of oligomeric free radicals with simvastatin while the epoxides arise from homolytic peroxide cleavage.