13365-63-4

Basic information

• Product Name: (4-Chlorophenyl)(2-furyl)methanone
• Synonyms: (4-Chlorophenyl)(2-furyl)methanone;(4-chlorophenyl)-furan-2-ylmethanone;(4-chlorophenyl)-furan-2-yl-methanone
• CAS NO: 13365-63-4
• Molecular Formula: C₁₁H₇ClO₂
• Molecular Weight: 206.62508
• Mol File: 13365-63-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 182 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4-Chlorophenyl)(2-furyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chlorophenyl)(2-furyl)methanone(13365-63-4)
• EPA Substance Registry System: (4-Chlorophenyl)(2-furyl)methanone(13365-63-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 13365-63-4(Hazardous Substances Data)

Usage

Description

(4-Chlorophenyl)(2-furyl)methanone, with the molecular formula C11H7ClO2, is a chemical compound that belongs to the class of ketone derivatives. It features a chlorophenyl group and a furyl group, which contribute to its unique chemical properties and potential applications.

Uses

Used in Pharmaceutical Synthesis:
(4-Chlorophenyl)(2-furyl)methanone is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex molecules with potential therapeutic properties, making it a valuable component in the development of new drugs.
Used in Agrochemical Production:
In addition to its pharmaceutical applications, (4-Chlorophenyl)(2-furyl)methanone is also utilized in the production of agrochemicals. Its chemical properties make it suitable for the development of compounds that can be used in the agricultural industry, such as pesticides or herbicides.
Used in Organic Chemistry:
(4-Chlorophenyl)(2-furyl)methanone serves as a building block in organic chemistry for constructing more complex molecules. Its versatility in forming different chemical structures makes it an important compound for researchers and chemists working on the synthesis of novel organic compounds.
Safety Precautions:
It is crucial to handle (4-Chlorophenyl)(2-furyl)methanone with care, as it may pose health hazards. It should only be used by trained professionals in a controlled laboratory setting to ensure safety and prevent potential risks.

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Downstream Products

• 111609-57-5 1-(4-Chloro-phenyl)-3,4-dihydro-pyrrolo[1,2-a]pyrazine 
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Relevant articles and documents

Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation

A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.

Ligand-free Pd-catalyzed carbonylative cross-coupling reactions under atmospheric pressure of carbon monoxide: Synthesis of aryl ketones and heteroaromatic ketones

The carbonylative Suzuki cross-coupling reactions of boronic acids with aryl iodides catalyzed by Pd2(dba)3 as a ligand-free catalyst under atmospheric pressure of carbon monoxide has been firstly developed. Under mild reaction conditions, a broad range of aryl/heteroaryl iodides and aryl/heteroaryl boronic acids were selectively coupled to afford the corresponding diaryl ketones in good to excellent yields at low catalyst loadings (0.05 to 2 mol-%). Moreover, the catalyst can also be recycled. The carbonylative Suzuki cross-coupling reactions of boronic acids with aryl iodides catalyzed by Pd2(dba)3 as a ligand-free catalyst under an atmosphere of carbon monoxide has been developed. A broad range of aryl/heteroaryl iodides and aryl/heteroaryl boronic acids were selectively coupled to afford the corresponding diaryl ketones in good to excellent yields. The catalyst can also be recycled.

Deprotonative metalation of functionalized aromatics using mixed lithium-cadmium, lithium-indium, and lithium-zinc species

In situ mixtures of CdCl2TMEDA (0.5 equiv; TMEDA = N,N,N',N'-tetramethylethylenediamine) or InCl3 (0.33 equiv) with [Li(tmp)] (tmp = 2,2,6,6-tetramethylpiperidino; 1.5 or 1.3 equiv, respectively) were compared with the previously described mixture of ZnCl2-TMEDA (0.5 equiv) and [Li(tmp)] (1.5 equiv) for their ability to deprotonate anisole, benzothiazole, and pyrimidine. [(tmp)3CdLi] proved to be the best base when used in tetrahydrofuran at room temperature, as demonstrated by subsequent trapping with iodine. The Cd-Li base then proved suitable for the metalation of a large range of aromatics including benzenes bearing reactive functional groups (CONEt2, CO2Me, CN, COPh) or heavy halogens (Br, I), and heterocycles (from the furan, thiophene, pyrrole, oxazole, thiazole, pyridine, and diazine series). Fivemembered heterocycles benefiting from doubly activated positions were similarly dideprotonated at room temperature. The aromatic lithium cadmates thus obtained were involved in palladium-catalyzed cross-coupling reactions or simply quenched with acid chlorides.