1337973-19-9

Basic information

• Product Name: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate
• Synonyms: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate
• CAS NO: 1337973-19-9
• Molecular Weight: 398.572
• Mol File: 1337973-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate(1337973-19-9)
• EPA Substance Registry System: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate(1337973-19-9)

Safety Data

• Hazardous Substances Data: 1337973-19-9(Hazardous Substances Data)

Upstream product

• 1227484-31-2 (5-bromo-2-methoxy-4-(methoxymethoxy)benzyloxy)(tert-butyl)dimethylsilane 
• 681-94-7 ethyl 2-(tributylstannyl)acetate 

Downstream Products

• 1227484-15-2 2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid 
• 1337973-24-6 (S)-3-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)butan-2-one 
• 1337973-25-7 (R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane 
• 1337973-28-0 (R)-2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)phenylmethanol 
• 1337973-13-3 (R)-2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzaldehyde 
• 1337973-29-1 (E)-3-(2-methoxy-4-(methoxymethoxy)-5-((R)-3-methylbut-3-en-2-yl)phenyl)-1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)prop-2-en-1-one 
• 1337973-11-1 (R)-licochalcone E 

Relevant articles and documents

Stereoselective total synthesis of (+)-licochalcone e

The synthesis of (+)-licochalcone E (1) was accomplished for the first time in 13 steps from aryl bromide (6) with 8% overall yield. Palladium-catalyzed Negishi-Reformatsky coupling reaction of compound 6 with ethyl 2-(tributylstannyl)acetate provided the aryl acetic ester (5), which was converted to aryl acetamide (4) via mixed anhydride formation. Chiral auxiliarymediated methylation of the (S)-4-benzyl-2-oxazolidinone-derived aryl acetamide (4) provided the key asymmetric benzylic methyl group in compound 1.