1338084-05-1

Basic information

• Product Name: C₁₃H₈N₆O₄S
• Synonyms: C₁₃H₈N₆O₄S
• CAS NO: 1338084-05-1
• Molecular Weight: 344.31
• Mol File: 1338084-05-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₈N₆O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₈N₆O₄S(1338084-05-1)
• EPA Substance Registry System: C₁₃H₈N₆O₄S(1338084-05-1)

Safety Data

• Hazardous Substances Data: 1338084-05-1(Hazardous Substances Data)

Upstream product

• 1338083-93-4 C₁₅H₁₂N₆O₄S 
• 5470-48-4 para-nitrobenzaldehyde thiosemicarbazone 
• 833-63-6 5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1338084-26-6 C₁₈H₁₇N₇O₅S 
• 1338083-71-8 C₁₃H₉N₇O₄S 

Relevant articles and documents

2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors

The enzymatic inhibition of histone deacetylase activity has come out as a novel and effectual means for the treatment of cancer. Two novel series of 2-[5-(4-substitutedphenyl)-[1,3,4]-oxadiazol/thiadiazol-2-ylamino] -pyrimidine-5-carboxylic acid (tetrahydro-pyran-2-yloxy)-amides were designed and synthesized as novel hydroxamic acid based histone deacetylase inhibitors. The antiproliferative activities of the compounds were investigated in vitro using histone deacetylase inhibitory assay and MTT assay. The synthesized compounds were also tested for antitumor activity against Ehrlich ascites carcinoma cells in Swiss albino mice. The efforts were also made to establish structure-activity relationships among synthesized compounds. The results of the present studying indicates 2,5-disubstituted 1,3,4-oxadiazole/thiadiazole as promising surface recognition moiety for development of newer hydroxamic acid based histone deacetylase inhibitor.