133815-20-0

Basic information

• Product Name: (-)-(4S,5S)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole
• Synonyms: (-)-(4S,5S)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole
• CAS NO: 133815-20-0
• Molecular Weight: 298.387
• Mol File: 133815-20-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: (-)-(4S,5S)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(4S,5S)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole(133815-20-0)
• EPA Substance Registry System: (-)-(4S,5S)-4,5-dihydro-2,4,5-triphenyl-1H-imidazole(133815-20-0)

Safety Data

• Hazardous Substances Data: 133815-20-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 951-87-1 meso-1,2-diphenyl-1,2-diaminoethane 
• 54874-97-4 N-(erythro-α'-amino-bibenzyl-α-yl)-benzamide 
• 92-29-5 hydrobenzamide 
• 92-29-5 (E,E)-1,3,5-triphenyl-2,4-diazapenta-1,4-diene 
• 80424-18-6 2,4,5-triphenylimidazolidine 
• 29841-69-8 (S,S)-1,2-diphenyl-1,2-diaminoethane 
• 825-60-5 benzimidic acid ethyl ester 
• 33722-46-2 isoamarine 
• 125134-03-4 (4R,5R-4,5-diphenyl-(1,3,2)-dioxathiolane-(2,2)-dioxide) 
• 618-39-3 benzamidin 
• 57-13-6 urea 
• 52340-78-0 (R,R)-hydroxybenzoin 

Downstream Products

• 58821-34-4 2r,3t,5,6-tetraphenyl-(6ξH)-7-oxa-1,4-diaza-bicyclo[4.1.0]hept-4-ene 
• 33722-46-2 isoamarine 
• 484-47-9 lophine 
• 3190-22-5 erythro-N-benzoyl-N'-phenylmethylidene-1,2-diamino-1,2-diphenylethane 
• 1092654-36-8 C₂₈H₂₄N₂O₂S 
• 1092654-37-9 C₂₂H₂₀N₂ 
• 33722-47-3 DL-(4R,5S)-1-benzyl-2,4,5-triphenyl-4,5-dihydro-1H-imidazole 
• 216861-21-1 (1S,2S)-N,N'-(1,2-diphenylethane-1,2-diyl)diacetamide 
• 91840-93-6 (1S,2S)-N,N'-diethyl-1,2-diphenyl-1,2-ethanediamine 
• 29841-69-8 (S,S)-1,2-diphenyl-1,2-diaminoethane 
• 40102-64-5 racem.-1,2-diphenyl-ethane-1,2-diamine; dihydrochloride 
• 951-87-1 rac-1,2-diphenylethylene-1,2-diamine 
• 911306-54-2 (+)-(1S,2S)-N-[(R)-α-acetoxyphenylacetyl]-N'-benzoyl-1,2-diamino-1,2-diphenylethane 
• 911306-52-0 (-)-(4S,5S)-1-[(R)-α-acetoxyphenylacetyl]-4,5-dihydro-2,4,5-triphenyl-1H-imidazole 

Relevant articles and documents

Nuclear factor-κB mediated inhibition of cytokine production by imidazoline scaffolds

The mammalian nuclear transcription factor NF-κB is responsible for the transcription of multiple cytokines, including the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Elevated levels of pro-inflammatory cytokines play an important role in the pathogenesis of inflammatory disorders such as rheumatoid arthritis (RA). Inhibition of the pro-inflammatory transcription factor NF-κB has therefore been identified as a possible therapeutic treatment for RA. We describe herein the synthesis and biological activity of a series of imidazoline-based scaffolds as potent inhibitors of NF-κB mediated gene transcription in cell culture as well as inhibitors of TNF-α and IL-6 production in interleukin 1 beta (IL-1β) stimulated human blood.

Solvent-free efficient synthesis of 2,4,5-triarylimidazolines from aromatic aldehydes and hexamethyldisilazane

A one-step preparation of 2,4,5-triarylimidazolines from aromatic aldehydes was accomplished by heating with hexamethyldisilazane under solvent-free conditions. This reaction provides a convenient preparative method for triarylimidazolines having a variety of aryl groups.

Convenient one-step synthesis of cis-2,4,5-triarylimidazolines from aromatic aldehydes with urea

A simple and efficient method has been developed for the synthesis of cis-2,4,5-triarylimidazolines based on a one-step procedure of aldehydes and urea in the presence of cesium carbonate. Taylor & Francis Group, LLC.

Fractional crystallisation of (±)-iso-amarine with mandelic acid: convenient access to (R,R)- and (S,S)-1,2-diamino-1,2-diphenylethanes

(±)-iso-Amarine can be conveniently resolved via 1:1 salt formation with either hand of mandelic acid. Enantiopure iso-amarine can be acetylated and hydrolysed to give enantiopure 1,2-diamino-1,2-diphenylethanes.

C3-symmetric chiral Trisimidazoline: Design and application to organocatalyst

(Figure Presented) C3-symmetric chlral trislmidazoline was designed and synthesized as a new entry of organocatalyst with the concept of constructing C3symmetric molecules with three C2-symmetric chiral components, and the application of this novel catalyst to asymmetric conjugate addition of β-ketoesters to nitroolefins was described.