1338235-60-1Relevant articles and documents
Copper-catalyzed intramolecular oxidative 6-exo-trig cyclization of 1,6-enynes with H2O and O2
Wang, Zhi-Qiang,Zhang, Wen-Wu,Gong, Lu-Bin,Tang, Ri-Yuan,Yang, Xu-Heng,Liu, Yu,Li, Jin-Heng
, p. 8968 - 8973 (2011/11/04)
The novel CuCl2-catalyzed title reaction of enynes has been developed for synthesizing substituted naphthoquinones (see scheme; DMA=dimethylacetamide). The method represents the first example of a copper-catalyzed enyne oxidative cyclization for constructing 1,4-naphthoquinones by the incorporation of two oxygen atoms into the organic framework from molecular oxygen and water.