1338374-99-4

Basic information

• Product Name: [1,1'-biphenyl]-4-yl-(8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
• Synonyms: [1,1'-biphenyl]-4-yl-(8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
• CAS NO: 1338374-99-4
• Molecular Weight: 409.491
• Mol File: 1338374-99-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [1,1'-biphenyl]-4-yl-(8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-biphenyl]-4-yl-(8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone(1338374-99-4)
• EPA Substance Registry System: [1,1'-biphenyl]-4-yl-(8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone(1338374-99-4)

Safety Data

• Hazardous Substances Data: 1338374-99-4(Hazardous Substances Data)

Upstream product

• 23936-11-0 3-methylpiperazin-2-one 
• 76003-30-0 tert-butyl 2-methyl-3-oxopiperazine-1-carboxylate 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 1429559-93-2 tert-butyl 8-methyl-3-(6-methylpyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 
• 98547-86-5 6-methyl-2-picolinic acid hydrazide 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 13602-11-4 6-methylpicolinic acid methyl ester 
• 1338373-03-7 tert-butyl 3-ethoxy-2-methyl-5,6-dihydropyrazine-1(2H)-carboxylate 

Relevant articles and documents

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.