133841-05-1

Basic information

• Product Name: 7-METHOXY-1H-INDAZOLE
• Synonyms: 7-METHOXY-1H-INDAZOLE;1H-Indazole, 7-methoxy-
• CAS NO: 133841-05-1
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Mol File: 133841-05-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 91-92 °C
• Boiling Point: 312.5 °C at 760 mmHg
• Flash Point: 114.6 °C
• Appearance: /
• Density: 1.244 g/cm³
• Vapor Pressure: 0.000968mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.33±0.40(Predicted)
• CAS DataBase Reference: 7-METHOXY-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-1H-INDAZOLE(133841-05-1)
• EPA Substance Registry System: 7-METHOXY-1H-INDAZOLE(133841-05-1)

Safety Data

• Hazardous Substances Data: 133841-05-1(Hazardous Substances Data)

Usage

Uses

7-Methoxy-1H-indazole is an inhibitor of neuronal nitric oxide synthase.

InChI:InChI=1/C8H8N2O/c1-11-7-4-2-3-6-5-9-10-8(6)7/h2-5H,1H3,(H,9,10)

Upstream product

• 64420-86-6 O-p-toluenesulfonyl benzyloxyhydroxamate 
• 54881-49-1 2-chloro-3-methoxy benzaldehyde 
• 77774-35-7 N-(2-hydroxy-6-methylphenyl)acetamide 
• 2835-97-4 2-amino-3-methylphenol 
• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 50868-76-3 N-(2-methoxy-6-methylphenyl)acetamide 
• 409321-32-0 C₈H₁₀N₂O₂ 

Downstream Products

• 351210-09-8 7-benzyloxyindazole 
• 351210-07-6 3-iodo-7-methoxy-1H-indazole 
• 81382-46-9 7-hydroxy-1H-indazole 

Relevant articles and documents

Facile synthesis of 3-trimethylsilylindazoles by [3+2]cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes

[3+2]Cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes, generated from halobenzenes, gave the corresponding 3-trimethylsilylindazoles in good to moderate yields.

NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.

Palladium-catalyzed cross-coupling of aryl chlorides and tosylates with hydrazine

Hydrazine is not a problem anymore: The title transformation is the first reaction to yield aryl hydrazines through the cross-coupling of aryl chlorides and tosylates with hydrazine. An appropriately designed palladium catalyst allows this reaction to proceed rapidly under mild conditions, and with excellent chemoselectivity (see scheme; Ad=adamantyl, Ts=4-toluenesulfonyl).