133860-75-0 Usage
Description
2-Chloro-N-(2-methylpropyl)-3-nitroquinolin-4-amine is a chemical compound derived from the quinoline family, featuring a chloro and nitro group, as well as a methylpropyl chain attached to the nitrogen atom. 2-chloro-N-(2-methylpropyl)-3-nitroquinolin-4-amine is known for its diverse range of biological activities, making it a valuable component in the development of pharmaceuticals and other applications.
Uses
Used in Pharmaceutical Industry:
2-Chloro-N-(2-methylpropyl)-3-nitroquinolin-4-amine is used as an intermediate compound for the synthesis of amine compounds with various therapeutic properties. Its presence in these compounds contributes to their anti-inflammatory, antifungal, antiparasitic, and anticancer activities, making it a crucial component in the development of new medications for a wide range of diseases and conditions.
Used in Preparation of Imiquimod:
2-Chloro-N-(2-methylpropyl)-3-nitroquinolin-4-amine is also utilized in the preparation of Imiquimod, a drug derived from dihydroxyquinoline. Imiquimod is known for its immunomodulatory and antiviral properties, and is commonly used in the treatment of external genital and anal warts, actinic keratosis, and superficial basal cell carcinoma. 2-chloro-N-(2-methylpropyl)-3-nitroquinolin-4-amine plays a vital role in the synthesis process, ensuring the effectiveness of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 133860-75-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,8,6 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 133860-75:
(8*1)+(7*3)+(6*3)+(5*8)+(4*6)+(3*0)+(2*7)+(1*5)=130
130 % 10 = 0
So 133860-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H14ClN3O2/c1-8(2)7-15-11-9-5-3-4-6-10(9)16-13(14)12(11)17(18)19/h3-6,8H,7H2,1-2H3,(H,15,16)
133860-75-0Relevant articles and documents
Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach
Kaneko, Daiki,Ninomiya, Masayuki,Yoshikawa, Rina,Ono, Yukari,Sonawane, Amol D.,Tanaka, Kaori,Nishina, Atsuyoshi,Koketsu, Mamoru
, (2020/10/06)
Imiquimod (1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine) is efficacious in topical therapy for certain types of skin cancers. Structurally similar EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) has been shown higher in vitro potency than imiquimod. Besides, triazole, oxadiazole, and thiadiazole rings are privileged building blocks in drug design. A series of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole and [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-thiadiazole derivatives were therefore synthesized by incorporation of these rings into the structure of EAPB0203 and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. Our findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents.
AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY
-
, (2014/08/19)
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
-
, (2008/06/13)
A process for the preparation of 1-substituted, 4-substituted-1H-imidazo[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates.