133869-78-0

Basic information

• Product Name: Biphenyl-4-carboxylic acid (2R,3S,5S)-5-(6-dimethylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester
• CAS NO: 133869-78-0
• Molecular Weight: 461.496
• Mol File: 133869-78-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Biphenyl-4-carboxylic acid (2R,3S,5S)-5-(6-dimethylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Biphenyl-4-carboxylic acid (2R,3S,5S)-5-(6-dimethylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester(133869-78-0)
• EPA Substance Registry System: Biphenyl-4-carboxylic acid (2R,3S,5S)-5-(6-dimethylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester(133869-78-0)

Safety Data

• Hazardous Substances Data: 133869-78-0(Hazardous Substances Data)

Upstream product

• 129468-51-5 methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 
• 938-55-6 6-Dimethylaminopurine 

Relevant articles and documents

Synthesis of 6-Dimethylaminopurine 2',3'-Dideoxynucleosides

The trimethylsilylated 6-dimethylaminopurine 1 was coupled with the 2',3'-dideoxyribose derivatives 2a, b and 7 by using trimethylsilyl triflate as catalyst to yield the corresponding nucleosides 3a, b, 4a, b and 8, which were appropriately deprotected to give the desired nucleosides 5a, b and 9 as well as the related α-isomers 6a, b and 10.The 2-deoxyribose derivative 12 was mesylated at the 3'-O-position to give 13 which was coupled similarly with 1 to yield compound 14 and its α-anomer 15.Compounds 14 and 15 were treated with tetrabutylammonium fluoride to give the desired 2',3'-didehydro-2',3'-dideoxynucleoside analogue 16 and its α-anomer 17. --- Key Words: Nucleosides, convergent synthesis / Nucleosides, 2',3'-dideoxy- / Nucleosides, 2',3'-didehydro- / Adenine, N6,N6-dimethylnucleosides