133914-73-5Relevant articles and documents
Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials
O'Neill, Paul M.,Mukhtar, Amira,Stocks, Paul A.,Randle, Laura E.,Hindley, Stephen,Ward, Stephen A.,Storr, Richard C.,Bickley, Jamie F.,O'Neil, Ian A.,Maggs, James L.,Hughes, Ruth H.,Winstanley, Peter A.,Bray, Patrick G.,Park, B. Kevin
, p. 4933 - 4945 (2007/10/03)
Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage. The observed drug toxicity is believed to involve the formation of an electrophilic metabolite, amodiaquine quinoneimin
Organic synthesis
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, (2008/06/13)
The conversion of ortho-hydroxylated Mannich bases to the corresponding methylated compounds, e.g., cresols, can be effectively carried out using a novel hydrogenation technique.