134038-91-8

Basic information

• Product Name: 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-diazo-2-propanone
• Synonyms: 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-diazo-2-propanone
• CAS NO: 134038-91-8
• Molecular Weight: 303.274
• Mol File: 134038-91-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-diazo-2-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-diazo-2-propanone(134038-91-8)
• EPA Substance Registry System: 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-diazo-2-propanone(134038-91-8)

Safety Data

• Hazardous Substances Data: 134038-91-8(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 111197-44-5 (4S)-4-(Chloroformyl)methyl-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one 
• 1152-61-0 N-Cbz-L-Asp 
• 23632-66-8 (4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one 

Downstream Products

• 1237501-67-5 C₁₄H₁₄BrNO₅ 
• 134038-93-0 4-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>methylthiazole 
• 119434-75-2 (S)-3-(4-thiazolyl)-2-tert-butoxycarbonylaminopropanoic acid 
• 157695-66-4 (S)-2-Benzyloxycarbonylamino-5-hydroxy-4-oxo-pentanoic acid 
• 134038-92-9 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-chloro-2-propanone 

Relevant articles and documents

Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase

The antifungal activity of 5-hydroxy-4-oxo-l-norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV-containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI-1640 medium, with minimal inhibitory concentration values in the 32 to 64?μg?mL?1 range. This activity was not affected by multidrug resistance that is caused by overexpression of genes encoding drug efflux proteins. The mechanism of antifungal action of HONV dipeptides involved uptake by the oligopeptide transport system, subsequent intracellular cleavage by cytosolic peptidases, and inhibition of homoserine dehydrogenase by the released HONV. The relative transport rates determined the anticandidal activity of HONV dipeptides.

SYNTHESIS OF CHIRAL LACTAMS AS TEMPLATES FOR ENZYME INHIBITORS: AN UNUSUAL ANNULATION IN THE INTRAMOLECULAR WADSWORTH-HORNER-EMMONS REACTION

Intramolecular carbonylolefination of a dipeptide keto phosphonate furnished unexpected lactams through rearrangement of the phosphonate carbanion.