134102-10-6

Basic information

• Product Name: rac-6-Fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic Acid Methyl Ester
• Synonyms: rac-6-Fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic Acid Methyl Ester;Methyl 6-Fluoro-3,4-dihydro--4-oxo-2H-1-benzopyran-2-carboxylate;methyl 6-fluoro-4-oxochroman-2-carboxylate
• CAS NO: 134102-10-6
• Molecular Formula: C₁₁H₉FO₄
• Molecular Weight: 224.1851632
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 134102-10-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: rac-6-Fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: rac-6-Fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic Acid Methyl Ester(134102-10-6)
• EPA Substance Registry System: rac-6-Fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic Acid Methyl Ester(134102-10-6)

Safety Data

• Hazardous Substances Data: 134102-10-6(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of hydroxylated Nebivolol metabolites.

Downstream Products

• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 874649-82-8 (-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate 
• 1355046-17-1 methyl 3-[(Z)-2-(1-benzyl-1H-imidazol-2-yl)-2-cyanovinyl]-4-chloro-6-fluoro-2H-chromene-2-carboxylate 
• 1354560-85-2 C₂₄H₂₅FN₂O₄ 
• 1354560-84-1 C₂₀H₁₈FNO₄ 
• 1354560-93-2 C₂₂H₂₀ClFN₂O₄ 
• 1354560-90-9 C₂₉H₂₅F₃N₂O₄ 

Relevant articles and documents

An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates

Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2′-hydroxy)phenylbutanoates derived from l-malic acid.