134108-76-2

Basic information

• Product Name: [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester
• Synonyms: [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester;[(1R,2R)-2-Hydroxycyclohexyl]carbamic Acid Phenylme thyl Ester,99%e.e.;[(1R,2R)-2-Hydroxycyclohexyl]carbamic Acid Phenylmethyl Ester, min. 98%
• CAS NO: 134108-76-2
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.30556
• Mol File: 134108-76-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 427.6±44.0 °C(Predicted)
• Appearance: white to light-yellow/Powder
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 11.90±0.40(Predicted)
• CAS DataBase Reference: [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(134108-76-2)
• EPA Substance Registry System: [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(134108-76-2)

Safety Data

• Hazardous Substances Data: 134108-76-2(Hazardous Substances Data)

Usage

Description

[(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester is a complex chemical compound belonging to the CarbaMic acid ester family. It features a cyclohexyl ring with a hydroxyl group in a specific (1R,2R) stereochemistry, along with a phenyl and a methyl group. This unique structure and properties may offer potential applications in various fields such as pharmaceuticals, organic synthesis, and materials science.

Uses

Used in Pharmaceutical Industry:
[(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester is used as a potential pharmaceutical compound for its unique structure and properties, which may contribute to the development of new drugs or therapies.
Used in Organic Synthesis:
In the field of organic synthesis, [(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester is used as a key intermediate or building block for the synthesis of more complex molecules with specific biological activities or applications.
Used in Materials Science:
[(1R,2R)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester is used as a component in the development of new materials with unique properties, such as improved mechanical strength, thermal stability, or chemical resistance, due to its specific chemical structure.

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Downstream Products

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Relevant articles and documents

Designing enzymatic resolution of amines

A new strategy, utilizing IR and mass spectrometry, has been developed to design appropriate reagents and reaction conditions for enantioselective enzymatic protection of amines with readily removable protecting groups.

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The invention discloses a method for preparing weinaweina kalland hydrochloride. The method to selectively amino protection, nucleophilic addition, nucleophilic substitution, deprotected, cyclized, reduction, into a salt by the reaction of the compound Wina carland hydrochloride. And after nuclear magnetic analysis test technology confirm its structure. It adopts the cheap and easily obtained starting materials to prepare, preparation method has advantages of simple operation, mild condition, easy industrialized production and the like, and avoids the use of heavy metal, is beneficial to the development of the oral. (by machine translation)

Enhanced rate and selectivity by carboxylate salt as a basic cocatalyst in chiral N-heterocyclic carbene-catalyzed asymmetric acylation of secondary alcohols

The rate and enantioselectivity of chiral NHC-catalyzed asymmetric acylation of alcohols with an adjacent H-bond donor functionality are remarkably enhanced in the presence of a carboxylate cocatalyst. The degree of the enhancement is correlated with the basicity of the carboxylate. With a cocatalyst and a newly developed electron-deficient chiral NHC, kinetic resolution and desymmetrization of cyclic diols and amino alcohols were achieved with extremely high selectivity (up to s = 218 and 99% ee, respectively) at a low catalyst loading (0.5 mol %). This asymmetric acylation is characterized by a unique preference for alcohols over amines, which are not converted into amides under the reaction conditions.