1341200-80-3

Basic information

• Product Name: 2,5-dichloro-N-(4-chlorophenyl)pyrimidin-4-amine
• Synonyms: 2,5-dichloro-N-(4-chlorophenyl)pyrimidin-4-amine
• CAS NO: 1341200-80-3
• Molecular Weight: 274.537
• Mol File: 1341200-80-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2,5-dichloro-N-(4-chlorophenyl)pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichloro-N-(4-chlorophenyl)pyrimidin-4-amine(1341200-80-3)
• EPA Substance Registry System: 2,5-dichloro-N-(4-chlorophenyl)pyrimidin-4-amine(1341200-80-3)

Safety Data

• Hazardous Substances Data: 1341200-80-3(Hazardous Substances Data)

Usage

Chemical Class

Halogenated pyrimidine derivative

Applications

Used as a building block in the synthesis of pharmaceuticals and agrochemicals.

Herbicidal Activity

Known for its selective herbicidal activity, effectively controlling a wide range of grass and broadleaf weeds in various crops.

Antifungal Potential

Demonstrates potential as an antifungal agent in agricultural applications.

Safety Concerns

Requires cautious handling and use due to potential hazards to human health and the environment if not properly managed.

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 5750-76-5 2,4,5-trichloropyrimidine 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1341200-81-4 5-chloro-2-((2,5-dichloropyrimidin-4-yl)amino)benzene-1-sulfonyl chloride 
• 1341200-82-5 2,5-dichloro-N-(4-chloro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidin-4-amine 
• 1341200-55-2 5-chloro-N₄-(4-chloro-2-(pyrrolidin-1-ylsulfonyl)phenyl)-N₂-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidine-2,4-diamine 
• 2284621-75-4 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide 
• 1620988-76-2 5-chloro-N⁴-(4-chlorophenyl)-N²-(1-(methylsulfonyl)piperidin-4-yl)pyrimidine-2,4-diamine 

Relevant articles and documents

Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water

Several types of reduction reactions in organic synthesis are performed under aqueous micellar-catalysis conditions (in water at ambient temperature), which produce a significant volume of foam owing to the combination of the surfactant and the presence of gas evolution. The newly engineered surfactant “Coolade” minimizes this important technical issue owing to its low-foaming properties. Coolade is the latest in a series of designer surfactants specifically tailored to enable organic synthesis in water. This study reports the synthesis of this new surfactant along with its applications to gas-involving reactions.

Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductions

A remarkable synergistic effect has been uncovered between ppm levels of Pd and Ni embedded within iron nanoparticles that leads to mild and selective catalytic reductions of nitro-containing aromatics and heteroaromatics in water at room temperature. NaBH4 serves as the source of inexpensive hydride. Broad substrate scope is documented, along with several other features including: low catalyst loading, low residual metal in the products, and recycling of the catalyst and reaction medium, highlight the green nature of this new technology.

Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1H)-pyrazole Derivatives as JAKs Inhibitors

Abnormalities in the JAK/STAT signaling pathway lead to many diseases such as immunodeficiency, inflammation, and cancer. Herein, we designed and synthesized a series of 4-amino-(1H)-pyrazole derivatives as potent JAKs inhibitors for cancer treatment. Res