134136-66-6

Basic information

• Product Name: 1-Propanone, 2-bromo-1-[4-[[tris(1-methylethyl)silyl]oxy]phenyl]-
• CAS NO: 134136-66-6
• Molecular Formula: C18H29BrO2Si
• Molecular Weight: 385.417
• Mol File: 134136-66-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-bromo-1-[4-[[tris(1-methylethyl)silyl]oxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-bromo-1-[4-[[tris(1-methylethyl)silyl]oxy]phenyl]-(134136-66-6)
• EPA Substance Registry System: 1-Propanone, 2-bromo-1-[4-[[tris(1-methylethyl)silyl]oxy]phenyl]-(134136-66-6)

Safety Data

• Hazardous Substances Data: 134136-66-6(Hazardous Substances Data)

Usage

Molecular weight

377.33 g/mol The relative molecular mass of the compound, based on the atomic weights of its constituent elements.

Appearance

Colorless to pale yellow liquid The compound is typically a liquid with a color that ranges from colorless to pale yellow.

Functional groups

Propanone, bromine, and phenyl group The compound contains these functional groups, which contribute to its reactivity and chemical properties.

Reactivity

Highly reactive The compound is known for its high reactivity, making it suitable for use in various chemical reactions and processes.

Hazardous nature

Potentially hazardous Due to its reactivity, this compound can be hazardous and should be handled with care in research and laboratory settings.

Uses

Organic synthesis and chemical research The compound is commonly used as a reagent in the preparation of various organic compounds and is found in research and laboratory settings.

Specific chemical and physical properties

The compound's unique combination of functional groups and molecular structure give it specific chemical and physical properties that make it suitable for a range of chemical reactions and processes.

Upstream product

• 70-70-2 4-hydroxypropiophenone 
• 13154-24-0 triisopropylsilyl chloride 
• 134136-88-2 1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one 

Downstream Products

• 134234-12-1 (+/-)-Traxoprodil 
• 134234-12-1 Traxoprodil 
• 134234-12-1 (+)-(1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino-1-yl)-1-propanol 
• 178375-17-2 1-(4-triisopropylsilyloxyphenyl)-2-(4-(3,5-dibromophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one 

Relevant articles and documents

NOVEL BENZOXATHIIN DERIVATIVE

Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent -CH-, a nitrogen atom or the like.

(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A potent new neuroprotectant which blocks N-methyl-D-aspartate responses

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol (20, CP-101,606) has been identified as a potent and selective N-methyl-D- aspartate (NMDA) antagonist through a structure activity relation (SAR) program based on ifenprodil, a known antihypertensive agent with NMDA antagonist activity. Sites on the threo-ifenprodil skeleton explored in this report include the pendent methyl group (H, methyl, and ethyl nearly equipotent; propyl much weaker), the spacer group connecting the C-4 phenyl group to the piperidine ring (an alternating potency pattern with 0 and 2 carbon atoms yielding the greatest potency), and simple phenyl substitution (little effect). While potent NMDA antagonists were obtained with a two atom spacer, this arrangement also increased α1 adrenergic affinity. Introduction of a hydroxyl group into the C-4 position on the piperidine ring resulted in substantial reduction in α1 adrenergic affinity. The combination of these observations was instrumental in the discovery of 20. This compound potently protects cultured hippocampal neurons from glutamate toxicity (IC50 = 10 nM) while possessing little of the undesired α1 adrenergic affinity (IC50 ~ 20 μM) of ifenprodil. Furthermore, 20 appears to lack the psychomotor stimulant effects of nonselective competitive and channel-blocking NMDA antagonists. Thus, 20 shows great promise as a neuroprotective agent and may lack the side effects of compounds currently in clinical trials.